Breast Cancer Stem Cells: Something Out of Notching?: Figure 1.
نویسندگان
چکیده
منابع مشابه
Breast cancer stem cells: something out of notching?
We and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucidated. Because inhibiting the Notch receptor signaling pathway is a possible fut...
متن کاملast Cancer Stem Cells: Something Out of Notching?
Downlo and others have established that the developmental Notch receptor signaling pathway is active in breast cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating rarchy of stem and progenitor cells in both normal and cancer epithelium has been elucidated. Because ing the Notch receptor signaling pathway is a possible future breast cancer...
متن کاملBreast cancer stem cells.
Breast cancer stem cells (BCSCs) constitute a subpopulation of tumor cells that express stem cell-associated markers and have a high capacity for tumor generation in vivo. Identification of BCSCs from tumor samples or breast cancer cell lines has been based mainly on CD44(+)/CD24(-/low) or ALDH(+) phenotypes. BCSCs isolation has allowed the analysis of the molecular mechanisms involved in their...
متن کاملBreast Cancer Stem Cells
Over 150 years ago, Cohnheim and Durante formalized the concept that cancers might arise from a small subset of cells with stem cell properties 1-3, and in 1961, Till and McCulloch demonstrated for the first time that the existence of hematopoietic stem cells (HSC) in the bone marrow, which was postulated that stem-like cells might be the origin of cancer 4. However, only recently did an increa...
متن کاملBreast cancer stem cells
Cancer metastasis, resistance to therapies and disease recurrence are significant hurdles to successful treatment of breast cancer. Identifying mechanisms by which cancer spreads, survives treatment regimes and regenerates more aggressive tumors are critical to improving patient survival. Substantial evidence gathered over the last 10 years suggests that breast cancer progression and recurrence...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2010
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-10-1559